翻訳と辞書 Words near each other ・ Phosphorus trifluoride (data page) ・ Phosphorus triiodide ・ Phosphorus triiodide (data page) ・ Phosphorus trioxide ・ Phosphorus trisulfide ・ Phosphorus-31 nuclear magnetic resonance ・ Phosphorus-32 ・ Phosphoryl bromide ・ Phosphoryl chloride ・ Phosphoryl chloride (data page) ・ Phosphoryl fluoride ・ Phosphoryl group ・ Phosphoglycolate phosphatase ・ Phosphogypsum ・ Phosphohydroxypyruvic acid ・ Phosphoinositide 3-kinase ・ Phosphoinositide 3-kinase inhibitor ・ Phosphoinositide 5-phosphatase ・ Phosphoinositide phospholipase C ・ Phosphoinositide-dependent kinase-1 ・ Phosphoketolase ・ Phospholamban ・ Phosphole ・ Phospholipase ・ Phospholipase A ・ Phospholipase A1 ・ Phospholipase A2 ・ Phospholipase B ・ Phospholipase C ・ Phospholipase D Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Phosphoinositide 3-kinase ： ウィキペディア英語版 Phosphoinositide 3-kinase Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinases, phosphatidylinositol-3-kinases, PI 3-kinases, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns).〔(myo-inositol )〕 The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in insensitivity of cancer tumors to insulin and IGF1, in calorie restriction. ==Discovery== The discovery of PI 3-kinases by Lewis Cantley and colleagues began with their identification of a previously unknown phosphoinositide kinase associated with the polyoma middle T protein. They observed unique substrate specificity and chromatographic properties of the products of the lipid kinase, leading to the discovery that this phosphoinositide kinase had the unprecedented ability to phosphorylate phosphoinositides on the 3' position of the inositol ring. Subsequently, Cantley and colleagues demonstrated that in vivo the enzyme prefers PtdIns(4,5)P2 as a substrate, producing the novel phosphoinositide PtdIns(3,4,5)P3. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Phosphoinositide 3-kinase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.